O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo L-tyrosine

Name	Thyroxine 4'-O-Sulfate
Synonyms	T4 Sulfate Thyroxine sulfate L-Thyroxine sulfate Thyroxine 4'-O-Sulfate Thyroxine 4'-O-Sulfate L-Thyroxine sulfate salt Thyroxine Hydrogen Sulfate O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo L-tyrosine L-Tyrosine, O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo-
CAS	77074-49-8

Molecular Formula	C15H11I4NO7S
Molar Mass	856.93
Density	2.658±0.06 g/cm3(Predicted)
pKa	-4.80±0.18(Predicted)
Storage Condition	2-8℃
In vitro study	Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate.
In vivo study	Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels.

Last Update：2024-01-02 23:10:35

biological activity	Thyroxine sulfate are thyroid hormone metabolites.
target	Human Endogenous Metabolite
in vitro study	Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate.
in vivo research	Significant amounts of thyroxine sulfate (T4S) in fetal sheet series, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). a significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate. Thyroxine undergoes significant sulfation in ats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 duration critical illness appears to play a role in this increase in serum T4S levels.

Last Update：2024-04-10 22:29:15

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Product Name: Thyroxine 4’-O-Sulfate Visit Supplier Webpage Request for quotation
CAS: 77074-49-8
Tel: 18301782025
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QQ: 3008007409

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